| Item Type | Name |
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Concept
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Action Potentials
|
|
Concept
|
Arrhythmias, Cardiac
|
|
Concept
|
Benzocaine
|
|
Concept
|
Amino Acid Sequence
|
|
Concept
|
Cats
|
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Concept
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Animals
|
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Concept
|
Anti-Arrhythmia Agents
|
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Concept
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Quaternary Ammonium Compounds
|
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Concept
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Anesthetics, Local
|
|
Concept
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Arginine
|
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Concept
|
Base Sequence
|
|
Concept
|
Aspartic Acid
|
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Concept
|
Cadmium
|
|
Concept
|
Binding Sites
|
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Concept
|
Barium
|
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Concept
|
Cell Separation
|
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Concept
|
Cnidarian Venoms
|
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Concept
|
Cardiotonic Agents
|
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Concept
|
Guinea Pigs
|
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Concept
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Dogs
|
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Concept
|
Electrophysiology
|
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Concept
|
Long QT Syndrome
|
|
Concept
|
Ethyl Methanesulfonate
|
|
Concept
|
Manganese
|
|
Concept
|
Cobalt
|
|
Concept
|
Drosophila melanogaster
|
|
Concept
|
Electric Conductivity
|
|
Concept
|
Atrial Natriuretic Factor
|
|
Concept
|
Isomerism
|
|
Concept
|
Heart
|
|
Concept
|
Heart Ventricles
|
|
Concept
|
Papillary Muscles
|
|
Concept
|
Dose-Response Relationship, Drug
|
|
Concept
|
Heart Atria
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Concept
|
Magnesium
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|
Concept
|
Models, Molecular
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|
Concept
|
Mammals
|
|
Concept
|
Models, Cardiovascular
|
|
Concept
|
Markov Chains
|
|
Concept
|
Monte Carlo Method
|
|
Concept
|
Purkinje Fibers
|
|
Concept
|
Microcomputers
|
|
Concept
|
Myocardial Contraction
|
|
Concept
|
Ion Channels
|
|
Concept
|
Isoleucine
|
|
Concept
|
Lidocaine
|
|
Concept
|
Mesylates
|
|
Concept
|
Microscopy, Electron
|
|
Concept
|
Peripheral Nervous System Neoplasms
|
|
Concept
|
Phenylalanine
|
|
Concept
|
Muscle Proteins
|
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Concept
|
Protein Conformation
|
|
Concept
|
Protein Synthesis Inhibitors
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|
Concept
|
Rabbits
|
|
Concept
|
Sea Anemones
|
|
Concept
|
Xenopus
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|
Concept
|
Potassium Channels
|
|
Concept
|
Sodium
|
|
Concept
|
Tetrodotoxin
|
|
Concept
|
Humans
|
|
Concept
|
United States
|
|
Concept
|
Tryptophan
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|
Concept
|
Xenopus laevis
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Concept
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Calcium Channels
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|
Concept
|
Isoquinolines
|
|
Concept
|
Sodium Channels
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|
Concept
|
Reverse Transcriptase Polymerase Chain Reaction
|
|
Concept
|
Moricizine
|
|
Concept
|
Rats, Sprague-Dawley
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|
Concept
|
Mutagenesis, Site-Directed
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|
Concept
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Myocardium
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|
Concept
|
Protein Structure, Tertiary
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|
Concept
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Connexins
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|
Concept
|
Methods
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|
Concept
|
Nickel
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|
Concept
|
Point Mutation
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|
Concept
|
Sequence Deletion
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|
Concept
|
Patch-Clamp Techniques
|
|
Concept
|
DNA, Complementary
|
|
Concept
|
Receptors, AMPA
|
|
Concept
|
Muscle, Skeletal
|
|
Concept
|
Tetraethylammonium
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|
Concept
|
Sodium Channel Blockers
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|
Concept
|
Neurotoxins
|
|
Concept
|
Nucleus Accumbens
|
|
Concept
|
Protein Structure, Secondary
|
|
Concept
|
Calcium Channels, T-Type
|
|
Concept
|
Intercellular Signaling Peptides and Proteins
|
|
Concept
|
History, 21st Century
|
|
Concept
|
Decapodiformes
|
|
Concept
|
Shaker Superfamily of Potassium Channels
|
|
Concept
|
Casein Kinase Idelta
|
|
Concept
|
Ryanodine Receptor Calcium Release Channel
|
|
Concept
|
Amino Acid Substitution
|
|
Concept
|
Mice
|
|
Concept
|
Rats, Inbred Strains
|
|
Concept
|
Sarcoplasmic Reticulum
|
|
Concept
|
Spiders
|
|
Concept
|
Rats
|
|
Concept
|
Static Electricity
|
|
Concept
|
Temperature
|
|
Concept
|
Zinc
|
|
Concept
|
Cardiac Electrophysiology
|
|
Concept
|
Delayed Rectifier Potassium Channels
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|
Concept
|
Polymerase Chain Reaction
|
|
Concept
|
Mibefradil
|
|
Concept
|
Brefeldin A
|
|
Concept
|
History, 20th Century
|
|
Concept
|
Axons
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|
Concept
|
Brain Neoplasms
|
|
Concept
|
Calcium
|
|
Concept
|
Calcium Channel Blockers
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|
Concept
|
Diastole
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|
Concept
|
Electrochemistry
|
|
Concept
|
Evoked Potentials
|
|
Concept
|
Fluorescent Dyes
|
|
Concept
|
Heart Conduction System
|
|
Concept
|
Lanthanum
|
|
Concept
|
Lysine
|
|
Concept
|
Membrane Potentials
|
|
Concept
|
Models, Biological
|
|
Concept
|
Neuroblastoma
|
|
Concept
|
Protons
|
|
Concept
|
Reaction Time
|
|
Concept
|
Saxitoxin
|
|
Concept
|
Systole
|
|
Concept
|
DNA Primers
|
|
Concept
|
Calcium Channels, L-Type
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|
Concept
|
Potassium Channels, Voltage-Gated
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|
Concept
|
Shab Potassium Channels
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Academic Article
|
Leucine 18, a hydrophobic residue essential for high affinity binding of anthopleurin B to the voltage-sensitive sodium channel.
|
|
Academic Article
|
Mechanism of cAMP-dependent modulation of cardiac sodium channel current kinetics.
|
|
Academic Article
|
The role of exposed tryptophan residues in the activity of the cardiotonic polypeptide anthopleurin B.
|
|
Academic Article
|
Structure and function of voltage-dependent sodium channels: comparison of brain II and cardiac isoforms.
|
|
Academic Article
|
Optimization of a mammalian expression system for the measurement of sodium channel gating currents.
|
|
Academic Article
|
Nonequilibrium response spectroscopy of voltage-sensitive ion channel gating.
|
|
Academic Article
|
Role for Pro-13 in directing high-affinity binding of anthopleurin B to the voltage-sensitive sodium channel.
|
|
Academic Article
|
A specific interaction between the cardiac sodium channel and site-3 toxin anthopleurin B.
|
|
Academic Article
|
Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8.
|
|
Academic Article
|
Modification of inactivation in cardiac sodium channels: ionic current studies with Anthopleurin-A toxin.
|
|
Academic Article
|
Voltage-dependent open-state inactivation of cardiac sodium channels: gating current studies with Anthopleurin-A toxin.
|
|
Academic Article
|
Augmentation of recovery from inactivation by site-3 Na channel toxins. A single-channel and whole-cell study of persistent currents.
|
|
Academic Article
|
Differences in the binding sites of two site-3 sodium channel toxins.
|
|
Academic Article
|
The Na channel voltage sensor associated with inactivation is localized to the external charged residues of domain IV, S4.
|
|
Academic Article
|
Gating of skeletal and cardiac muscle sodium channels in mammalian cells.
|
|
Academic Article
|
The role of the putative inactivation lid in sodium channel gating current immobilization.
|
|
Academic Article
|
Point mutations in domain III of a Drosophila neuronal Na channel confer resistance to allethrin.
|
|
Academic Article
|
Heartthrobs.
|
|
Academic Article
|
Lidocaine alters activation gating of cardiac Na channels.
|
|
Academic Article
|
Two components of use-dependent block of sodium current by lidocaine in voltage clamped cardiac Purkinje cells.
|
|
Academic Article
|
Atrionatriuretic peptide and calcium-conducting sodium channels.
|
|
Academic Article
|
Arg-14 loop of site 3 anemone toxins: effects of glycine replacement on toxin affinity.
|
|
Academic Article
|
Role of Asn-16 and Ser-19 in anthopleurin B binding. Implications for the electrostatic nature of Na(V) site 3.
|
|
Academic Article
|
Charge immobilization of the voltage sensor in domain IV is independent of sodium current inactivation.
|
|
Academic Article
|
Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.
|
|
Academic Article
|
Molecular action of lidocaine on the voltage sensors of sodium channels.
|
|
Academic Article
|
State-dependent mibefradil block of Na+ channels.
|
|
Academic Article
|
Kinetic analysis of single sodium channels from canine cardiac Purkinje cells.
|
|
Academic Article
|
Gating currents associated with Na channels in canine cardiac Purkinje cells.
|
|
Academic Article
|
Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.
|
|
Academic Article
|
A profile of alternative RNA splicing and transcript variation of CACNA1H, a human T-channel gene candidate for idiopathic generalized epilepsies.
|
|
Academic Article
|
Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.
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|
Academic Article
|
Sodium channels in cardiac Purkinje cells.
|
|
Academic Article
|
Isoform-dependent interaction of voltage-gated sodium channels with protons.
|
|
Academic Article
|
Open sodium channel properties of single canine cardiac Purkinje cells.
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|
Academic Article
|
Site-3 toxins and cardiac sodium channels.
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|
Academic Article
|
An inner pore residue (Asn406) in the Nav1.5 channel controls slow inactivation and enhances mibefradil block to T-type Ca2+ channel levels.
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|
Academic Article
|
Is there a second external lidocaine binding site on mammalian cardiac cells?
|
|
Academic Article
|
An intact connexin N-terminus is required for function but not gap junction formation.
|
|
Academic Article
|
Use-dependent block of sodium current by ethmozin in voltage-clamped internally perfused canine cardiac Purkinje cells.
|
|
Academic Article
|
Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel.
|
|
Academic Article
|
The sodium channel as a target for local anesthetic drugs.
|
|
Academic Article
|
Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.
|
|
Academic Article
|
Sodium channel molecular conformations and antiarrhythmic drug affinity.
|
|
Academic Article
|
A direct effect of forskolin on sodium channel bursting.
|
|
Academic Article
|
Effects of inotropic interventions on end systolic length-force curve of cat ventricular muscle.
|
|
Academic Article
|
Sodium current in voltage clamped internally perfused canine cardiac Purkinje cells.
|
|
Academic Article
|
Mechanisms of extracellular divalent and trivalent cation block of the sodium current in canine cardiac Purkinje cells.
|
|
Academic Article
|
Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination.
|
|
Academic Article
|
Time-dependent changes in kinetics of Na+ current in single canine cardiac Purkinje cells.
|
|
Academic Article
|
Modification of sodium channel inactivation by alpha-chymotrypsin in canine cardiac Purkinje cells.
|
|
Academic Article
|
Evidence for multiple effects of ProTxII on activation gating in Na(V)1.5.
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|
Academic Article
|
A structural motif for the voltage-gated potassium channel pore.
|
|
Academic Article
|
Extracellular divalent and trivalent cation effects on sodium current kinetics in single canine cardiac Purkinje cells.
|
|
Academic Article
|
Dose-dependent modulation of the cardiac sodium channel by sea anemone toxin ATXII.
|
|
Academic Article
|
Inhibition of the activation pathway of the T-type calcium channel Ca(V)3.1 by ProTxII.
|
|
Academic Article
|
Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study.
|
|
Academic Article
|
The outermost lysine in the S4 of domain III contributes little to the gating charge in sodium channels.
|
|
Academic Article
|
Polyvalent cations constitute the voltage gating particle in human connexin37 hemichannels.
|
|
Academic Article
|
Outward stabilization of the voltage sensor in domain II but not domain I speeds inactivation of voltage-gated sodium channels.
|
|
Academic Article
|
Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels.
|
|
Concept
|
NAV1.2 Voltage-Gated Sodium Channel
|
|
Concept
|
NAV1.5 Voltage-Gated Sodium Channel
|
|
Concept
|
Voltage-Gated Sodium Channel beta-3 Subunit
|
|
Concept
|
NAV1.3 Voltage-Gated Sodium Channel
|
|
Grant
|
Cardiac Channels: Targets of Drugs that Affect Kinetics
|
|
Grant
|
STRUCTURAL BASES OF T-TYPE CALCIUM CHANNEL FUNCTION
|
|
Grant
|
Structure-Function of the Cardiac Sodium Channel
|
|
Grant
|
Drug therapy targeted to the voltage-gated sodium channel
|